{
  "macrophages": {
    "IFN response": ["STAT1", "IRF1", "GBP1", "GBP4", "CXCL9", "CXCL10"],
    "MHC-II presentation": ["HLA-DRA", "HLA-DRB1", "HLA-DPA1", "HLA-DPB1", "CD74", "CIITA"],
    "Immunoregulatory TAM": ["CD163", "MRC1", "MSR1", "STAB1", "MERTK"],
    "Lipid-associated TAM": ["APOE", "TREM2", "LPL", "GPNMB", "SPP1"],
    "C1Q TAM": ["C1QA", "C1QB", "C1QC", "APOE"],
    "Inhibitory signaling": ["IL10", "TGFB1", "CD274", "IDO1", "LGALS9"]
  },
  "t_cells": {
    "Cytotoxicity": ["PRF1", "GZMB", "GZMA", "GNLY", "NKG7", "CTSW"],
    "Exhaustion-associated": ["PDCD1", "LAG3", "HAVCR2", "TIGIT", "TOX", "ENTPD1"],
    "Progenitor-memory-like": ["TCF7", "LEF1", "IL7R", "SLAMF6", "CXCR5"],
    "Treg-associated": ["FOXP3", "IL2RA", "CTLA4", "IKZF2", "TIGIT"],
    "Proliferation": ["MKI67", "TOP2A", "STMN1", "TYMS"],
    "Tissue residency": ["CD69", "ITGAE", "CXCR6", "ZNF683", "ITGA1"]
  },
  "tumor_candidates": {
    "MHC-I presentation": ["HLA-A", "HLA-B", "HLA-C", "B2M", "TAP1", "TAP2", "NLRC5"],
    "IFN response": ["STAT1", "IRF1", "IFIT1", "IFIT3", "GBP1", "CXCL9", "CXCL10"],
    "Proliferation": ["MKI67", "TOP2A", "PCNA", "MCM2", "MCM5", "UBE2C"],
    "Hypoxia": ["CA9", "VEGFA", "SLC2A1", "BNIP3", "PDK1"],
    "Osteogenic differentiation": ["RUNX2", "SP7", "ALPL", "COL1A1", "IBSP", "BGLAP"],
    "Checkpoint-evasion-associated": ["CD274", "PDCD1LG2", "CD47", "LGALS9", "PVR"],
    "DNA repair-associated": ["RAD51", "BRCA1", "FANCD2", "CHEK1", "EXO1"],
    "Stress-resistance-associated": ["ATF4", "DDIT3", "HSPA5", "ABCB1", "ABCC1"]
  }
}